The silence was held in memory of 66 Rangers fans who lost their lives in the 1971 Ibrox stadium disaster.
But a shout of “I hope you die” was heard ringing around the stadium just seconds before the minute silence was up.
It is not known which side the shout came from but it has been met with near-universal condemnation.
“I hope you die”
Players from both sides were clearly seen shaking their heads in disappointment when the observation was disrupted.
It came despite Celtic legend Bertie Auld pleaded with supporters to keep the peace.
He said: “Remember those who died and pay the people involved the respect they deserve.
“Something like the Ibrox disaster brings you down to Earth and I am sure the fans will remember that.”
Scott Brown – £25,000 per week
Celtic boss Brendan Rodgers added: “The tragedy at Ibrox was one which affected Rangers FC and so many other people across Scotland.
“It transcended football and also involved Celtic so closely.
“As we have done many times, we’ll pay respects and remember sincerely those who lost their lives in tragic circumstances.”